MLB scores, schedule and odds: Wednesday, April 21, 2027

The MLB schedule for Wednesday, April 21, 2027 has 15 games.

First up: Cubs at Diamondbacks at 12:00 AM ET on MLB.TV.

• Chicago Cubs at Arizona Diamondbacks — Wed, Apr 21 12:00 AM ET · Chase Field, Phoenix
• Cincinnati Reds at Miami Marlins — Wed, Apr 21 12:00 AM ET · loanDepot park, Miami
• Cleveland Guardians at Toronto Blue Jays — Wed, Apr 21 12:00 AM ET · Rogers Centre, Toronto
• Detroit Tigers at Chicago White Sox — Wed, Apr 21 12:00 AM ET · Rate Field, Chicago
• Houston Astros at Los Angeles Angels — Wed, Apr 21 12:00 AM ET · Angel Stadium, Anaheim
• New York Mets at Athletics — Wed, Apr 21 12:00 AM ET · Sutter Health Park, Sacramento
• San Francisco Giants at Pittsburgh Pirates — Wed, Apr 21 12:00 AM ET · PNC Park, Pittsburgh
• Tampa Bay Rays at Boston Red Sox — Wed, Apr 21 12:00 AM ET · Fenway Park, Boston
• Minnesota Twins at St. Louis Cardinals — Wed, Apr 21 1:15 PM ET · Busch Stadium, St. Louis
• Seattle Mariners at Texas Rangers — Wed, Apr 21 2:40 PM ET · Globe Life Field, Arlington
• Kansas City Royals at Baltimore Orioles — Wed, Apr 21 6:35 PM ET · Oriole Park at Camden Yards, Baltimore
• Los Angeles Dodgers at Philadelphia Phillies — Wed, Apr 21 6:40 PM ET · Citizens Bank Park, Philadelphia
• Milwaukee Brewers at New York Yankees — Wed, Apr 21 7:05 PM ET · Yankee Stadium, Bronx
• Washington Nationals at Atlanta Braves — Wed, Apr 21 7:15 PM ET · Truist Park, Atlanta
• San Diego Padres at Colorado Rockies — Wed, Apr 21 8:40 PM ET · Coors Field, Denver